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Acne Control The Natural Way!
Want to get rid of those zits in your face but you are currently low on budget? How about looking for acne control to avoid the sudden appearance of acne in your skin? So how do we do this?
First, what is acne? Acne is a skin disorder caused by...
Acne Prevention Tips
Have you experienced disappointments while staring at a mirror? Certainly because you do not want what you are seeing for you might have your greatest nightmare— of having a pimple! Commonly from sweet 16 to fabulous 40 and so on, acne occurs much....
Acne Products Made Affordable
With so many acne products out there, finding the right one for you can be an expensive process. However, it doesn't have to be if you know the right things to look for. When comparing acne products, spend a little less time looking at the marketing...
Curing Acne Naturally - Effective Herbal Acne Treatments
Chances are, if you find yourself reading this article, you have suffered the feelings of embarassment, self-consciousness and insecurity an acne breakout can bring on in what seems like the blink of an eye. Suddenly, you find yourself checking the...
What is my acne really trying to tell me?
Most acne products do nothing more than waste money. Imagine spending hundreds of dollars on creams and lotions only to find out they didn't really work or only gave you temporary relief. Acne remains a serious problem for a lot of teenagers ...
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Spironolactone in the treatment of acne
In his article on acne published recently in the New England Journal of Medicine James (1) mentions that androgen antagonist spironolacton is often useful in women with hyperandrogenism. However, it would be important to point out, that the effectiveness of this treatment cannot be determined due to the small sample populations involved in the trials, as has been shown in recent metaanalysis. (2) It should be also emphasized that although the long-term use of spironolactone in the treatment of acne in women appears to be safe, its side-effects seem to be high. (3) On the other hand, it is worth mentioning that spironolactone in addition to its antiandrogenic effects might also have antiinflammatory potential. (4) This emphasizes the need for further properly designed trials with relevant outcomes to provide robust estimates of the size and mechanism of any treatment effects. Because of its long half-life spironolactone should be given once daily and not in divided doses as recommended by James. This might
increase the compliance which is important in prolonged therapy to achieve maximal benefits. (5)
1. James WD. Clinical practice. Acne. N Engl J Med 2005;352:1463-72.
2. Farquhar C, Lee O, Toomath R, Jepson R. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2003;(4):CD000194.
3. Shaw JC, White LE. Long-term safety of spironolactone in acne: results of an 8-year followup study. J Cutan Med Surg 2002;6:541-5.
4. Hansen PR, Rieneck K, Bendtzen K. Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunol Lett 2004;91:87-91.
5. McEvoy B, Nydegger R, Williams G. Factors related to patient compliance in the treatment of acne vulgaris. Int J Dermatol 2003;42:274-80.
About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia.
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